Name | N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide |
Synonyms | WSCI WSCD WATER-SOLUBLE CARBODIIMIDE [3-(Dimethylamino)propyl]ethylcarbodiimide 1-(3-dimethylaminopropyl)-N-ethylcarbodiimide 1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide |
CAS | 1892-57-5 |
EINECS | 217-579-2 |
InChI | InChI=1/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3 |
InChIKey | LMDZBCPBFSXMTL-UHFFFAOYSA-N |
Molecular Formula | C8H17N3 |
Molar Mass | 155.24 |
Density | 0.877 g/mL at 20 °C (lit.) |
Melting Point | 115℃ |
Boling Point | 66-68°C/1mm |
Flash Point | 66-68°C/1mm |
Water Solubility | Soluble in water. |
Solubility | Chloroform |
Vapor Presure | 0.373mmHg at 25°C |
Appearance | Clear Liquid |
Specific Gravity | 0.885 |
Color | Colorless to slightly yellow |
BRN | 507429 |
pKa | 9.52±0.28(Predicted) |
Storage Condition | -20°C |
Sensitive | Air Sensitive |
Refractive Index | n20/D 1.461 |
MDL | MFCD00044916 |
Hazard Symbols | C - Corrosive |
Risk Codes | 34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2735 8/PG 3 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 1-3-10 |
TSCA | Yes |
HS Code | 29252900 |
Hazard Class | 8 |
Packing Group | III |
Reference Show more | 1. Jiao Yanhua, Liang Yuanyuan, Guo Weiqiang. Research on HCG chemiluminescence immunoassay based on magnetic microspheres [J]. Journal of Hangzhou Normal University (Natural Science Edition), 2014, 000(005):495-498. 2. Liu Hong, Mao Xiang, Shuang Liu Huan, et al. Preparation of PEG Modified Fe_3O_4 Nanoparticles (MNPs) and Study on Catalytic Oxidation of VB_1 [J]. Journal of Tianjin Agricultural University 2018. 3. He, B., Du, G. Novel electrochemical aptasensor for ultrasensitive detection of sulfadimidine based on covalently linked multi-walled carbon nanotubes and in situ synthesized gold nanoparticle composites. Anal Bioanal Chem 410, 2901-2910 (2018). https:// do 4. Li, Xiangyu, et al. "Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis." RSC Advances 11.6 (2021): 3567-3574.https:// doi.org/10.1039/D0RA08689D 5. [IF = 4.316] Dan Cheng et al. "An Electrochemical DNA Sensing Platform Using Carboxyl Functionalized Graphene as the Electrode Modified Material." J Electrochem Soc. 2017 Apr;164(6): h345 6. [IF = 2.896] Bao-Shan He et al. "Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification." Anal Methods-Uk. 2018 Feb;10(7):783 7. [IF = 11.161] Ye Lili et al. "Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors." J Exp Clin Canc Res. 2021 Dec;40(1):1-16 8. [IF = 5.03] Delu Zhao et al. "Effect of altering photocrosslinking conditions on the physical properties of alginate gels and the survival of photoencapsulated cells." Polym Degrad Stabil. 2020 Sep;179:109297 9. [IF = 3.361] Xiangyu Li et al. "Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis." Rsc Adv. 2021 Jan;11(6): 3567-3574 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
introduction | 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is a condensing agent, colorless or light yellow liquid, commonly used as its hydrochloride. |
Use | 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, referred to as EDC hydrochloride, is a water-soluble peptide coupling agent and a general carbonyl activation reagent. It can be used to bond amides with secondary amines, react with phosphate groups, cross-link proteins with nucleic acids, and prepare such as immune crosslinks, used for carbonyl modification in proteins, etc. |